Figure 4 | Scientific Reports

Figure 4

From: Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency

Figure 4

HuNoV distribution in Gn pigs.

HuNoV genomes in stomach (Sto), duodenum (Duo), jejunum (Jej), ileum and mesentery (Mes) from pigs euthanized on PID3 (a), PID10 (b) and PID28 (c) were measured by qRT-PCR. (d) Total HuNoV genomes in intestinal contents were measured by qRT-PCR. HuNoV genomes in plasma (e) and whole blood cells (f) were measured by qRT-PCR. (a–d) WT groups, PID3 n = 3, PID10 n = 3, PID n = 5; RAG2/IL2RG deficiency groups, PID3 n = 3, PID10 n = 5, PID n = 4. (e,f) Sample sizes are shown in Table 1. Dashed line indicates limit of detection. Data are presented as mean ± s.e.m. with individual animal data points. Statistical significance was determined by Student’s t-test (a) or Mann-Whitney test (b–f). *P < 0.05, **P < 0.01.

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