Figure 2

PAC of iEEG signals during an ictal state in patient G.
(a) The averaged SI values during the ictal state are shown for all combinations of phase and amplitude frequencies. The ictal state was defined as 120 s from the onset of the first seizure. (b) The SI values of β-high γ were colour-coded for each contact over time during the ictal state. (c) The averaged SI of β-high γ values during the ictal state was colour-coded at the location of each contact in a normalised brain. The yellow arrowhead indicates the epileptogenic zone. The white arrowhead indicates the contact no. 45. (d) For each contact in all the patients, Student’s t-test was used to identify significant differences between the averaged SI values and the averaged phase-shuffled SI values during the ictal state. The t-values were colour-coded for each combination of phase and amplitude frequency.