Table 2 Pharmacokinetic profile in vaginal lavage.

From: Triple combination MPT vaginal microbicide using curcumin and efavirenz loaded lactoferrin nanoparticles

Parameters

Units

EFV *

Curcumin #

ECNPs

Sol (EFV + Cur)

ECNPs

Sol (EFV + Cur)

AUC

(h)*(mg/ml)

20.4164

13.7581

32.4251

21.9066

AUMC

(h)^2*(mg/ml)

132.482

52.448

172.922

56.496

C max

mg/mL

4.9126

4.2897

9.7794

8.9723

T max

hr

2

1

2

1

t 1/2

hr

4.63222

2.14916

3.97347

1.8513

  1. Pharmacokinetic parameters.
  2. AUC: The integral of the concentration-time curve (after a single dose or in steady state).
  3. AUMC: Partial area under the moment curve between t start and t end.
  4. Cmax: The peak plasma concentration of a drug after oral administration.
  5. Tmax: Time to reach Cmax.
  6. t1/2: The time required for the concentration of the drug to reach half of its original value.
  7. *EFV credentials measured individually when delivered via ECNPs and Sol (EFV+Cur) respectively.
  8. #Cur credentials measured individually when delivered via ECNPs and Sol (EFV+Cur) respectively.
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