Table 2 Up- and down-regulated genes in preterm infants with sepsis ordered by expression value (Panel A) and Comparison of gene expression (fold change) between data obtained from feces in the present study in preterm infants with sepsis and those from blood cells also in septic preterm newborn described in a previous study (Panel B).
Panel A: Up-and-Down regulated genes | p-value | Fold Change | ||
|---|---|---|---|---|
UPREGULATED GENES | ||||
TBC1D2B | similar to TBC1 domain family, member 2B | 0.0404223 | 2.105 | |
C3orf79 | hypothetical protein LOC152118 | 0.0435912 | 1.896 | |
ZNF487P | zinc finger protein 487, pseudogene | 0.0325316 | 1.789 | |
PSG4 | pregnancy specific beta-1-glycoprotein 4 | 0.049411 | 1.649 | |
GSTM2 | glutathione S-transferase mu 2(muscle) | 0.0199524 | 1.618 | |
LEP | leptin | 0.0307164 | 1.582 | |
CLK2 | CDC-like kinase 2 | 0.0464448 | 1.578 | |
AQP7 | aquaporin 7 | 0.0271608 | 1.559 | |
RPS9 | ribosomal protein S9 | 0.0403301 | 1.554 | |
RNU11 | RNA, U11 small nuclear | 0.0348921 | 1.513 | |
Greatest significance level | ||||
CD40LG | CD40 ligand | 6.6 × 105 | 1.209 | |
FAM58A | family with sequence similarity 58, member A | 2.4 × 104 | 1.463 | |
CPEB1 | cytoplasmic polyadenylation element binding protein | 9.8 × 104 | 1.208 | |
C7orf70 | family with sequence similarity 220, member A | 0.0012 | 1.428 | |
FARS2 | Phenyl-alanyl-tRNA synthetase 2, mitochondrial | 0.0016 | 1.193 | |
DOWNREGULATED GENES | p-value | expression value | ||
ZNRD1 | zinc ribbon domain containing 1 | 0.0036632 | −2.012 | |
TRAPPC3 | trafficking protein particle complex 3 | 0.0152393 | −1.813 | |
SLC25A44 | solute carrier family 25, member 44 | 0.0426276 | −1.782 | |
LCE2C | late cornified envelope 2C | 0.032163 | −1.676 | |
LCN1 | lipocalin 1 | 0.0386323 | −1.660 | |
AMZ2P1 | archaelysin family metallopeptidase 2 pseudogene 1 | 0.0462527 | −1.649 | |
SYNJ2BP | synaptojanin 2 binding protein | 0.0189059 | −1.582 | |
C1QTNF9B | C1q and tumor necrosis factor related protein 9B | 0.0223451 | −1.574 | |
SLC45A4 | solute carrier family 45, member 4 | 0.0449936 | −1.538 | |
LARP4 | La ribonucleoprotein domain family, member 4 | 0.0393834 | 0.670 | |
Greatest significance level | ||||
PSKH2 | protein serine kinase H2 | 0.0010 | −1.257 | |
LONP2 | lon peptidase 2, peroxisomal | 0.0016 | −1.297 | |
TSTD2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 | 0.0019 | −1.305 | |
ZNF514 | zinc finger protein 514 | 0.0024 | −1.120 | |
OAZ2 | ornithine decarboxylase antizyme 2 | 0.0032 | −1.211 | |
Panel B) | ||||
Feces | Blood (Ref. 24 ) | |||
p-value | Fold change | p-value | Fold change | |
C7orf70 | 0.00119 | 1.43 | 0.000796 | −1.25 |
OSCAR | 0.02477 | 1.29 | 0.000388 | 1.39 |
ARID5A | 0.03141 | 1.29 | 0.000002 | 1.47 |
CD40LG | 0.00007 | 1.21 | 0.000069 | −2.20 |
IL18R1 | 0.01898 | −1.07 | 0.000004 | 3.15 |
SMYD2 | 0.02760 | −1.12 | 0.000432 | −1.60 |
HP | 0.04761 | −1.20 | 0.000082 | 4.17 |
TBC1D8 | 0.00796 | −1.27 | 0.00013 | 2.17 |
CD3E | 0.032 | −1.27 | 0.000783 | −1.96 |