Table 2 Up- and down-regulated genes in preterm infants with sepsis ordered by expression value (Panel A) and Comparison of gene expression (fold change) between data obtained from feces in the present study in preterm infants with sepsis and those from blood cells also in septic preterm newborn described in a previous study (Panel B).

From: Sepsis in preterm infants causes alterations in mucosal gene expression and microbiota profiles compared to non-septic twins

Panel A: Up-and-Down regulated genes

p-value

Fold Change

UPREGULATED GENES

 TBC1D2B

similar to TBC1 domain family, member 2B

0.0404223

2.105

 C3orf79

hypothetical protein LOC152118

0.0435912

1.896

 ZNF487P

zinc finger protein 487, pseudogene

0.0325316

1.789

 PSG4

pregnancy specific beta-1-glycoprotein 4

0.049411

1.649

 GSTM2

glutathione S-transferase mu 2(muscle)

0.0199524

1.618

 LEP

leptin

0.0307164

1.582

 CLK2

CDC-like kinase 2

0.0464448

1.578

 AQP7

aquaporin 7

0.0271608

1.559

 RPS9

ribosomal protein S9

0.0403301

1.554

RNU11

RNA, U11 small nuclear

0.0348921

1.513

Greatest significance level

 CD40LG

CD40 ligand

6.6 × 105

1.209

 FAM58A

family with sequence similarity 58, member A

2.4 × 104

1.463

 CPEB1

cytoplasmic polyadenylation element binding protein

9.8 × 104

1.208

 C7orf70

family with sequence similarity 220, member A

0.0012

1.428

 FARS2

Phenyl-alanyl-tRNA synthetase 2, mitochondrial

0.0016

1.193

DOWNREGULATED GENES

 

p-value

expression value

 ZNRD1

zinc ribbon domain containing 1

0.0036632

−2.012

 TRAPPC3

trafficking protein particle complex 3

0.0152393

−1.813

 SLC25A44

solute carrier family 25, member 44

0.0426276

−1.782

 LCE2C

late cornified envelope 2C

0.032163

−1.676

 LCN1

lipocalin 1

0.0386323

−1.660

 AMZ2P1

archaelysin family metallopeptidase 2 pseudogene 1

0.0462527

−1.649

 SYNJ2BP

synaptojanin 2 binding protein

0.0189059

−1.582

 C1QTNF9B

C1q and tumor necrosis factor related protein 9B

0.0223451

−1.574

 SLC45A4

solute carrier family 45, member 4

0.0449936

−1.538

 LARP4

La ribonucleoprotein domain family, member 4

0.0393834

0.670

Greatest significance level

 PSKH2

protein serine kinase H2

0.0010

−1.257

 LONP2

lon peptidase 2, peroxisomal

0.0016

−1.297

 TSTD2

thiosulfate sulfurtransferase (rhodanese)-like domain containing 2

0.0019

−1.305

 ZNF514

zinc finger protein 514

0.0024

−1.120

 OAZ2

ornithine decarboxylase antizyme 2

0.0032

−1.211

Panel B)

 

Feces

Blood (Ref. 24 )

  

p-value

Fold change

p-value

Fold change

C7orf70

0.00119

1.43

0.000796

−1.25

OSCAR

0.02477

1.29

0.000388

1.39

ARID5A

0.03141

1.29

0.000002

1.47

CD40LG

0.00007

1.21

0.000069

−2.20

IL18R1

0.01898

−1.07

0.000004

3.15

SMYD2

0.02760

−1.12

0.000432

−1.60

HP

0.04761

−1.20

0.000082

4.17

TBC1D8

0.00796

−1.27

0.00013

2.17

CD3E

0.032

−1.27

0.000783

−1.96

  1. (see ref. 24).