Figure 6 | Scientific Reports

Figure 6

From: Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes

Figure 6

Co-localization of gliadin T-cell and B-cell epitopes in an ω-gliadin protein (accession number: Q9FUW7).

The 9mer core sequences of known T-cell epitopes recognized by HLA-DQ restricted CD4 + T cells in celiac disease13 are highlighted in different colors. The hmAb epitope QPQQPFP is framed. Of note, the sequence of the native protein is given and glutamine (Q) residues that are targeted by TG2 for modification to glutamic acid are not marked.

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