Figure 6
miR-221 promotes breast cancer cell invasion via reducing E-cadherin.
(a) Invasion of MCF-7 cells transfected with pre-miR-221 or scrambled control oligonucleotide (pre-miR-NTC). (b) Invasion of MDA-MB-231 cells transfected with anti-miR-221 ASO or control ASO (anti-CTL ASO). (c) Invasion of MCF-7 cells transfected with or without E-cad (WT) ORF or pre-miR-221. (d) Invasion of MDA-MB-231 cells transfected with or without E-cad (WT) ORF, or anti-miR-221 ASO. (e) Invasion of MCF-7 cells transfected with or without E-cad (MUT) ORF, or pre-miR-221. (f) Invasion of MDA-MB-231 cells transfected with or without E-cad (MUT) ORF or anti-miR-221 ASO. Results are presented as the mean ± SEM (n = 3). NS, no significant difference, *P < 0.05. **P < 0.01.
