Figure 4 | Scientific Reports

Figure 4

From: A systems biology pipeline identifies new immune and disease related molecular signatures and networks in human cells during microgravity exposure

Figure 4

Consensus non-negative matrix factorization (NMFC) clustering on leading edge genes.

(a) Cophenetic coefficient as a function of number of clusters for downregulated leading edge genes from canonical pathways for E-GEOD-38836. The arrow indicates the maximum number of mathematically stable clusters possible in this example. (b) Maximum number of mathematically stable clusters plausible for other experiments. Clusters with upregulated and downregulated genes are shown in black and red bars respectively.

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