Table 1 Half-maximal inhibitory concentration (IC50, μM) for the binding of PIB to Aβ aggregates determined using 99mTc-Ham complexes as ligands.

From: Imaging of Cerebral Amyloid Angiopathy with Bivalent 99mTc-Hydroxamamide Complexes

Compound

IC50 of PIB (μM)*

Aβ(1–40)

Aβ(1–42)†

[99mTc]SB1A

0.38 ± 0.06

0.72 ± 0.10

[99mTc]SB1B

0.45 ± 0.11

0.38 ± 0.08

[99mTc]SB2A

4.59 ± 0.77

16.40 ± 2.47

[99mTc]SB2B

3.37 ± 0.61

2.55 ± 0.45

[99mTc]BT1A

0.24 ± 0.06

0.26 ± 0.02

[99mTc]BT1B

0.99 ± 0.17

0.47 ± 0.05

[99mTc]BT2A

1.58 ± 0.27

2.80 ± 0.32

[99mTc]BT2B

4.96 ± 0.90

5.78 ± 0.53

  1. *Values are the mean ± standard error of the mean of 6–15 independent experiments.
  2. †Data from our previous article (ref. 35).
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