Figure 4: Acute in vivo toxicity of SET-M33L, SET-M33L-PEG and colistin at 40 mg/Kg, 20 mg/Kg and 10 mg/Kg, given in a single dose. | Scientific Reports

Figure 4: Acute in vivo toxicity of SET-M33L, SET-M33L-PEG and colistin at 40 mg/Kg, 20 mg/Kg and 10 mg/Kg, given in a single dose.

From: In vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate

Figure 4: Acute in vivo toxicity of SET-M33L, SET-M33L-PEG and colistin at 40 mg/Kg, 20 mg/Kg and 10 mg/Kg, given in a single dose.

Ten mice/group (each circle represents one mouse) were inoculated i.v. with SET-M33L, SET-M33L-PEG or colistin and were monitored for 96 hours. Different scales of grey indicate severity of signs as described in the legend. Toxicity scores were rated as described in Material and Methods.

Back to article page