Table 2 Antibacterial activities of selected HKAIs for a panel of clinical isolates and reference strains.

From: Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens

Strain

MIC (μg/ml)

F1

F1.6

F1.8

F2.3

F2.4

F2.8

S1.7

S1.13

S1.14

Staphylococcus aureus

 20231

25

125

125

125

250

31

250

8

500

 25293

125

250

250

125

125

250

125

8

125

 274/08

125

500

250

>500

500

250

250

16

250

 V4180

125

>500

250

250

500

250

>500

8

250

 T4/6

125

250

250

250

>500

250

250

8

250

 145/08

125

250

250

250

250

250

>500

8

250

 127/08

n.d

250

250

250

500

250

>500

16

250

 S908

n.d

500

250

250

500

n.d.

>500

16

250

Staphylococcus epidermidis

 20044

4

500

63

31

500

31

>500

1

500

 RP62A

>500

>500

500

125

> 500

250

>500

8

>500

 RP62A/1

250

>500

250

125

n. d.

250

>500

8

500

 T7/3

63

125

31

31

n. d.

63

>500

8

250

 T37/8

>500

>500

500

125

n. d.

250

>500

16

500

 T6119

>500

>500

250

125

n. d.

250

>500

8

500

Streptococcus suis

 3881/S10

>500

>500

250

>500

250

125

>500

8

125

Streptococcus pneumoniae

 49619

n. d.

256

128

4

64

n. d.

128

16

>500

Acinetobacter baumannii

 NM109

n. d.

n. d.

125

n. d.

500

n. d.

>500

>500

250

 NM124

n. d.

n. d.

125

n. d.

500

n. d.

>500

>500

250

 NM8

>500

>500

125

>500

500

>500

>500

>500

500

 NM35

n. d.

n. d.

125

n. d.

>500

n. d.

>500

>500

500

 NM75

n. d.

n. d.

250

n. d.

>500

n. d.

>500

>500

500

Stenotrophomonas maltophilia

 B5/5

n. d.

n. d.

n. d.

n. d.

>500

n. d.

>500

>500

500

 B6/2

n. d.

n. d.

n. d.

n. d.

500

n. d.

>500

>500

500

 B32/1

>500

>500

>500

>500

500

>500

>500

>500

500

Escherichia coli

 CFT 073

>500

>500

250

>500

500

63

>500

>500

>500

 ATCC 25276

>500

>500

250

>500

500

500

>500

>500

>500

Klebsiella pneumoniae

 ATCC700603

>500

>500

250

>500

>500

250

>500

>500

>500

Pseudomonas aeruginosa

 ATCC 27853

>500

>500

500

>500

>500

>500

>500

>500

>500

  1. n.d.–not tested.