Figure 7: RNA seq analysis. | Scientific Reports

Figure 7: RNA seq analysis.

From: Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase

Figure 7: RNA seq analysis.

Differentially expressed genes in the kidneys of treated mice with FDR < 0.05 and a fold change cutoff of 1.5 were used to query pathways databases including Ingenuity Pathway Analysis and the MetaCore database. Significantly modulated genes from top ranked pathways (by FDR) are listed in the RNAseq heatmap using z score of normalized gene expression level. The results were from one experiment (10 mg/kg BI-BTK-1 treated, n = 7; VC, n = 6; HC, n = 5).

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