Figure 1
From: Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia
N-methylhemeanthidine chloride (NMHC) suppressed acute myeloid leukemia cell proliferation.
(a) The chemical structure of NMHC. (b) Effects of NMHC on viability of a variety of hematological malignant cells. (c) Effects of NMHC on acute myeloid leukemia cell viability. Above all, designated cells were treated with indicated concentrations of NMHC for 48 h and cell viability was evaluated using CCK8 kits. Relative cell viability is presented as an average ratio to PBS treatment from triplicate wells ± SD. P-values were derived from Student’s t-test (*P < 0.05, **P < 0.01; NMHC treatments vs DMSO treatments).
