Figure 3
From: Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia
NMHC treatments affected expression of genes involved in apoptosis, acute myeloid leukemogenesis and the NOTCH signaling pathway.
(a) Heatmap presentation of altered gene expression upon NMHC treatments. Addition of 1 ÎĽM NMHC in HL-60 cell culture was followed by total RNA preparation and microarray analysis. Differential gene expression was clustered as shown. GSEA analysis of apoptosis (b), acute myeloid leukemia (c) and the NOTCH signaling pathway (d) was presented. (e) Comparison of NMHC-modulated genes and DLL4-regulated genes derived from GSE422616.
