Figure 4 | Scientific Reports

Figure 4

From: Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function

Figure 4

The effects of VNS on dendritic spine density.

The representative images from invert bright field of dendritic spines (A,D) The representative 3D rendering of dendritic spine density was constructed using the Filament Tracer module of the Imaris Suite 7.0® software to generate spine reconstructions of the acquired invert bright field z-stack images (B,E) The representative overlay images from invert bright field of dendritic spines and 3D rendering (C,F) Upper panel (A–C) showed the representative dendritic spine density of sham group. Lower panel (D–F) showed the representative dendritic spine density of VNS group. (G) The effect of VNS or sham on the number of dendritic spines at CA1 region of hippocampus. Sham: sham-operated HFD-fed rats; VNS: VNS-treated HFD-fed rats (N = 8 of each group) *p < 0.05 in comparison with the sham group.

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