Figure 1: IVD space is narrowed in LSI mice.
From: Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis
(A) Lumbar spine instability mouse model (LSI). Mouse L3–L5spinous processes were resected along with the supraspinous and interspinous ligaments to induce instability of lumbar spine. (B) Mid-sagittalL4–L5μCT image of LSI and sham mice. Arrows indicate narrowed IVD space. (C) Coronal plane of cranial and caudal L4–L5EPs (3D reconstruction of μCT image). IVD space indicated by red color. (D) Quantification of L4–L5 IVD volume. Mice analyzed at 0, 2, 4 and 8 weeks post-sham or LSI surgery. Scale bar, 1 mm. n = 8 per group. Data are shown as mean ± s.d. *p < 0.05, **p < 0.01.
