Figure 6: Inhibition of excess active TGFβ attenuates EP degeneration in CSI mice.
From: Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis
(A) Caudal spine instability mouse model (CSI). The instability of caudal spine was induced by full depth annular stab and NP removal of the C7–8 IVD. CSI or Shan mice were treated with either vehicle (Veh) or TβRI inhibitor (SB) as indicated. C7–8 EPs were analyzed. (B) Coronal plane of C7–8 IVD space indicated by red color. Scale bar, 1 mm. (C) Coronal plane of five consecutive images were used for 3D reconstruction of caudal EPs. Scale bar, 1 mm. (D–F) Quantification of IVD volume, cranial (E) and caudal (F) EP volume by μCT analysis. (G) 3D-images of CT-based microangiography. Scale bar 200 μm. n = 6 per group. Data are shown as mean ± s.d. **p < 0.01, *p < 0.05.
