Figure 3
From: Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication
mRNA expression of 84 genes that are part of the type I IFN signal transduction pathway has been assessed by real-time quantitative RT-PCR, calculated relative to five housekeeping genes and shown as fold-change expression from the untreated sample.
Gene expression (nfold) is shown as a color scale from green to red (−2 to +9) (MEV multiple experiment viewer software). (a) Uninfected and HIV1-infected (day 7 post infection) PBMCs cultured in medium containing TIZ (10 μg/mL); (b) Uninfected and HIV1-infected (day 7 post infection) PBMCs cultured in medium containing RM-4848 (10 μg/mL). Only targets showing at least a 2-fold modulation were considered significative and shown in tabs.
