Table 2 MIC and MBC of the peptides against bacteria.

From: Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida

Peptides

MIC a (MBC b ) (μM)

Gram-negative bacteria

Gram-positive bacteria

E. coli 25922

E. coli EC183

E. coli 1005

S. typhi C77-31

S. aureus 29213

S. aureus 25923

S. epidermidis 12228

B. subtilis 63501

PMAP-36

1 c (4)

1 (1)

2 c (2)

1 c (2)

2 c (4)

2 c (4)

2 c (4)

1 (1)

RI21

2 (8)

1 (2)

2 (2)

1 (2)

4 (4)

4 (4)

4 (8)

1 (4)

RI18

2 (4)

1 (2)

2 (4)

2 (4)

4 (4)

8 (8)

4 (16)

1 (2)

TI15

8 (16)

2 (4)

4 (8)

8 (32)

32 (128)

32 (128)

32 (64)

2 (4)

RI12

8c (32)

2 (4)

16c (32)

8c (32)

64c (128)

128c (128)

64c (64)

2 (8)

melittin

2c (4)

2 (2)

2c (4)

2c (2)

8c (16)

8c (8)

0.5c (1)

1 (2)

  1. aMinimum inhibitory concentration (MIC) was determined as the lowest concentration of peptide that inhibited bacteria growth. Data are representative of three independent experiments.
  2. bMinimum bactericidal concentration (MBC) was determined as the lowest concentration of peptide that killed at least 99.9% of the initial inoculums. Data are representative of three independent experiments.
  3. cMIC values were determined as previously described15.
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