Table 3 MIC and MFC of the peptides against fungi.

From: Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida

Peptides

MIC a (MFC b ) (μM)

C. albicans 2.2086

C. albicans CA276

C. tropicalis 2.1975

C. krusei 2.1857

PMAP-36

128 (128)

128 (128)

1 (2)

8 (8)

RI21

8 (16)

8 (32)

1 (2)

2 (4)

RI18

16 (32)

8 (16)

2 (4)

4 (8)

TI15

64 (64)

128 (128)

2 (4)

8 (16)

RI12

128 (128)

128 (128)

8 (8)

16 (16)

melittin

4 (8)

8 (16)

2 (2)

2 (4)

Amphotericin B

0.25 (0.25)

0.5 (1)

0.25 (1)

1 (1)

Fluconazole

2 (2)

2 (2)

0.25 (1)

64 (64)

  1. aMinimum inhibitory concentration (MIC) was determined as the lowest concentration of peptide that inhibited fungal growth. Data are representative of three independent experiments.
  2. bMinimum fungicidal concentration (MFC) was determined as the lowest concentration of peptide that killed at least 99.9% of the initial inoculums. Data are representative of three independent experiments.
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