Table 4 MHC, GM and SI of the peptides.

From: Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida

Peptides

MHC a (μM)

GM b (μM)

SI c

Bacteria

Fungi

Bacteria

Fungi

PMAP-36

4

1.41

19.03

2.84

0.21

RI21

32

2.00

3.36

16

9.52

RI18

128

2.38

5.66

53.78

22.61

TI15

>128

8.72

19.03

29.36

13.45

RI12

>128

14.67

38.05

17.45

6.73

melittin

0.25

2.18

3.36

0.11

0.07

  1. aMHC is the minimum hemolytic concentration that caused 5% hemolysis of human red blood cells (hRBCs). Data are representative of three independent experiments.
  2. bThe geometric mean (GM) of the MIC values of the peptides against bacteria and fungi was calculated.
  3. cSelectivity index (SI) is the ratio of MHC to GM. Larger SI values indicate greater cell selectivity. When no detectable hemolytic activity was observed at 128 μM, a value of 256 μM was used to calculate SI.
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