Figure 5
From: Phototheranostics of CD44-positive cell populations in triple negative breast cancer
In vivo PIT with different dosing strategies.
(a) Representative photographs of excised tumors (two from each group) from nude mice bearing bilateral MDA-MB-231 tumors at the end of 3-week treatment. A single i.v. injection of 300 μg of immunoconjugates/controls was dosed. (b) Representative photographs of excised tumors (two from each group) from nude mice bearing bilateral MDA-MB-231 tumors at the end of 3-week treatment. Two i.v. injections (at one week interval) of 100 μg of CD44-IR700 were given. One tumor (left) was exposed to NIR irradiation at 30 J/cm2 with a wavelength of 680 nm at 24-h p.i. and the contralateral one (right) was covered by aluminum foil. The tumor growth curves of 300 μg injection (c) and two i.v. injections (d) over 3 weeks p.i. Values represent means ± SD (n = 4 per group, *P < 0.05, **P < 0.01 for the irradiated MDA-MB-231 tumors from CD44-IR700-injected mice compared to other control groups using Student’s t test).
