Table 4 Association between the MTRR 66A > G dominant model and survival of gastric cancer patients among various chemotherapy regimen subgroups.

From: The effects of genomic polymorphisms in one-carbon metabolism pathways on survival of gastric cancer patients received fluorouracil-based adjuvant therapy

MTRR66A > G

Chemotherapy Based on DDP and 5-FU

Genotype

Patients, n = 140

Deaths, n = 69

MST (months)

log-rank p

HR (95% CI) a

 AA

90

47

50

0.494

1

 GA/GG

50

22

60 b

 

0.839 (0.506–1.393)

Chemotherapy Based on L-OHP and 5-FU

Genotype

patients, n = 140

Deaths, n = 46

MST (months)

log-rank p

HR (95% CI) a

 AA

65

27

62

0.035

1

 GA/GG

75

19

92 b

 

0.538 (0.299–0.970)

  1. aAdjusted for age and sex.
  2. bMean survival time was provided when MST could not be calculated.