Figure 6 | Scientific Reports

Figure 6

From: CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination

Figure 6

Context-independent relationship between epitope-specificity and effector function.

Epitope-specific reactivity for individual specificities were compared as ratios of reactive Tfh:NonTfh as shown previously for (a) infection (Fig. 2) and (b) HA/NP vaccination (Fig. 3). Data from previous figures on infection and vaccination were duplicated below for comparison of the response to the inserted epitope in MalE. (c) The ratio of reactive cells (Tfh:NonTfh) for each epitope is depicted for MalE133 vaccination, as calculated from enumeration of IL-2 producing cells in each population (Fig. 5). Statistical significance determined by 1-way ANOVA with Tukey post test. *p < 0.05; **p < 0.01; ***p < 0.001.

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