Table 1 Metabolic data from the four groups after 4 weeks of dietary treatment.

From: Osteopontin deficiency reduces kidney damage from hypercholesterolemia in Apolipoprotein E-deficient mice

 

ApoE-/-ND

ApoE-/-HD

ApoE-/-/OPN-/-ND

ApoE-/-/OPN-/-HD

Significance (P value)

n = 6

n = 6

n = 6

n = 6

Gene

Diet

Gene x Diet

Body weight (g)

25.17 ± 0.31

23.17 ± 0.17

25.67 ± 0.33

23.83 ± 0.31

NS

< 0.05

NS

Kidney weight (mg)

183.33± 2.11

165 ± 3.41

183.33 ± 4.94

168.33 ± 4.77

NS

< 0.05

NS

TC (mg/dl)

458 ± 39.47

2065± 138.42

362.5 ± 34.12

1640 ± 189.64

< 0.05

< 0.01

NS

LDL-C (mg/dl)

107.17 ± 12.1

519.17 ± 25.4

77.83 ± 5.32

414.17 ± 41.52

< 0.05

< 0.01

NS

TG (mg/dl)

119 ± 31.36

43.33 ± 9.89

92.5 ± 24.02

31.67 ± 3.07

NS

< 0.05

NS

BUN (mg/dl)

27.8 ± 2.49

29.58 ± 1.65

23.35 ± 1.75

27.25 ± 1.5

NS

NS

NS

  1. Abbreviations: TC, total cholesterol; LDL-C, low-density lipoprotein- cholesterol; TG, triglycerides; BUN, blood urea nitrogen. Data are analyzed by two-way ANOVA; n = 6 per group. NS, not significant.
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