Figure 4: Conformational changes of D1 upon tubulin binding.

(a) Overview. Uncomplexed D1 (in orange, C-cap in yellow) has been superimposed on D1 in tubulin−D1 (D1 in green with the C-cap in brighter color, β tubulin in beige), taking the N-cap and the internal repeats as a reference. (b) Close-up (only β tubulin and uncomplexed D1 are shown). Without a C-cap rotation, its residues would clash with tubulin. Five distances shorter than 2 Å are highlighted as black solid lines.