Figure 1: Ethanol decreases the NAD+/NADH ratio and SIRT1 activity to cause PPARγ acetylation. | Scientific Reports

Figure 1: Ethanol decreases the NAD+/NADH ratio and SIRT1 activity to cause PPARγ acetylation.

From: Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis

Figure 1

(a) Schedule of ethanol and control diet regimens. (b) H&E staining performed on liver sections from mice. (c) Hepatic TG and cholesterol content, liver weight, serum aspartate transaminase (AST) alanine transaminase (ALT) levels, and NAD+/NADH ratio in the livers of control diet and ethanol diet-fed mice. (n = 6 per group) (d) Western blot analysis of SIRT1, PPARγ, and β-actin. (n = 5 per group) (e) PPARγ acetylation in control and ethanol diet-fed mice. (n = 3 per group) (f) Expression of PPARγ and SREBP1c and their target genes in control and ethanol diet-fed mice. (n = 6–8 per group) Data represent the mean ± SD. *P < 0.05, **P < 0.01.

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