Figure 6
Crystal structures of (A). Sso10a1 (PDB code 1RJ7 (18)) and (B). Sso10a2 (PDB code 4WH0). The Sso10a dimer consists of an anti-parallel coiled-coil (magenta/blue) with two DNA-binding winged helix-turn-helix motifs (red/cyan) on opposite sides of the coiled-coil. The main structural differences between Sso10a1 and Sso10a2 are the length of the β-sheet wing and the relative position of the α3-helices, which are thought to be important for DNA interactions. (C) Sso10a1 and Sso10a2 aligned on the lower α3-helix, illustrating the difference in relative position and orientation of the two α3-helices.
