Figure 1
Illustration of ROI placement.
(A) OEF at baseline, (B) OEF map at 2 hrs after embolisation. ROIs were placed in a core (ROI 1), an ischaemic penumbra (ROI 2) and normal white matter (ROI 3). (C) Raw image of the ASE sequence, which is used to locate the ROIs. (D) DWI image at the same slice as the OEF map. The cortices of the right hemisphere and medial cortex of the left hemisphere showed a high signal (white arrow). E: T2WI image of the same slice as OEF map and DWI image. (F) TTC staining slice corresponding to the DWI image and OEF map. Infarct lesions in cortices of the right hemisphere are depicted (straight arrow) that were whitened and consistent with a high signal on DWI imaging. Some cortices in the left hemisphere were swollen but with normal colour, defined as ischaemic penumbra (curved arrow). (G–I) Microscopic views of the core (ROI 1), penumbra (ROI 2) and white matter area (ROI 3) (haematoxylin and eosin staining, ×400). Marked neuronal degeneration is shown in the core (G) whereas cell oedema is predominant in the penumbra region (H). Normal white matter depicts normal neuronal cells without nuclear karyolysis and neuronal cell loss (I).
