Table 2 Patient Characteristics by Benign (Non-Atypia) versus Malignant (Invasive Cancer) Disease Status.

From: The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease

Variable

Total (N = 28)

Invasive Cancer (n = 15)

Benign non-atypia (n = 13)

p-value1

Age

   

0.001

Median (Range)

60 (33–84)

75 (44–84)

49 (33–70)

 

Menopausal status, n (%)

   

0.02

Pre-menopause

8 (28.6%)

2 (13.3%)

6 (46.2%)

 

Peri-menopause

2 (7.1%)

0

2 (15.4%)

 

Post-menopause

18 (64.3%)

13 (86.7%)

5 (38.5%)

 

BMI category, n (%)

   

0.17

18.5–24.9

6 (21.4%)

4 (26.7%)

2 (15.4%)

 

25–29.9

13 (46.4%)

8 (53.3%)

5 (38.5%)

 

≥30

9 (32.1%)

3 (20.0%)

6 (46.2%)

 

Smoking status, n (%)

   

0.28

Former smoker

10 (35.7%)

4 (26.7%)

6 (46.2%)

 

Never smoker

18 (64.3%)

11 (73.3%)

7 (53.8%)

 

Diabetes mellitus, n (%)

   

0.63

No

25 (89.3%)

13 (86.7%)

12 (92.3%)

 

Yes, NIDDM

3 (10.7%)

2 (13.3%)

1 (7.7%)

 

Prior ipsilateral breast surgery, n (%)

   

0.26

No

27 (96.4%)

14 (93.3%)

13 (100%)

 

Yes

1 (3.6%)

1 (6.7%)

0

 

Parity, n (%)

   

0.76

0

4 (14.3%)

2 (13.3%)

2 (15.4%)

 

1–3

19 (67.9%)

10 (66.7%)

9 (69.2%)

 

>3

5 (17.9%)

3 (20.0%)

2 (15.4%)

 

Breastfed ever, n (%)

   

1.0

No

12 (57.1%)

8 (57.1%)

4 (57.1%)

 

Yes

9 (42.9%)

6 (42.9%)

3 (42.9%)

 

Missing

7

1

6

 

Family history of breast cancer, n (%)

   

0.49

No

17 (60.7%)

10 (66.7%)

7 (53.8%)

 

Yes

11 (39.3%)

5 (33.3%)

6 (46.2%)

 

Distance of specimen from nipple, n (%)

   

0.53

≤2 cm

4 (14.3%)

2 (13.3%)

2 (15.4%)

 

>2 cm and ≤5 cm

11 (39.3%)

5 (33.3%)

6 (46.2%)

 

>5 cm

13 (46.4%)

8 (53.3%)

5 (38.5%)

 

Time from incision to sample collection, minutes

    

Median (range)

69 (30–206)

82 (54–206)

52 (30–72)

<0.0001

  1. 1P-value was calculated using Wilcoxon rank-sum tests for continuous variables, chi-square tests for nominal variables and Cochran-Armitage trend tests for ordinal variables.
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