Table 4 Clinical and laboratory characteristics of analysed patients.
Feature | PBC (n = 118) | PSC (n = 115) | P value |
|---|---|---|---|
Age (years) | 57.7 ± 11.4 | 35.4 ± 13.3 | <0.0001 |
Gender (M/F) | 9 (7.6%)/109 (92.4%) | 75 (65.2%)/40 (34.8%) | <0.0001 |
Cirrhosis* (yes/no) | 53 (46.1%)/62 (53.9%) | 30 (26.1%)/85 (73.9%) | <0.01 |
Child-Pugh class** (A/B/C) | 29 (54.7%)/18 (34.0%)/6 (11.3%) | 16 (53.3%)/12 (40%)/2 (6.7%) | 0.73 |
Haemoglobin (g/dL) | 12.4 ± 1.7 | 13.1 ± 2.0 | 0.01 |
Platelets (10^3/μL, Normal: 150–400) | 190 ± 117 | 227 ± 110 | 0.02 |
ALT (IU/L; Normal: <30) | 80 ± 114 | 93 ± 90 | 0.34 |
AST (IU/L; Normal: <30) | 77 ± 67 | 71 ± 51 | 0.48 |
ALP (IU/L; Normal: <120) | 255 ± 206 | 299 ± 195 | 0.11 |
GGT (IU/L; Normal: <42) | 302 ± 506 | 279 ± 315 | 0.69 |
Bilirubin (mg/dL; Normal: <1.0) | 2.6 ± 4.5 | 3.0 ± 5.6 | 0.56 |
Albumin (g/dL; Normal: 3.8–4.4) | 3.8 ± 0.5 | 4.2 ± 0.5 | <0.0001 |
INR (Normal: 0.8–1.2) | 1.1 ± 0.2 | 1.1 ± 0.1 | 0.36 |
Total bile acids (nM) | 43 850.1 ± 47081.1 | 44 751.7 ± 58 058.1 | 0.79 |
Creatinine (mg/dl; Normal: <1.0) | 0.9 ± 0.4 | 0.8 ± 0.2 | <0.001 |
UDCA response (yes/no)*** | 54 (50.5%)/53 (49.5%) | — | — |
Mayo Risk Score **** | 5.9 ± 1.8 | −0.1 ± 1.3 | — |
MELD | 9.7 ± 4.2 | 9.8 ± 4.5 | 0.77 |
ATX activity (nmol/mL*min) | 10.2 ± 4.4 | 7.3 ± 3.4 | <0.0001 |
