Table 1 Comparison of vacuoles induced by “Non-Toxic” complex with those caused by other vacuolating toxins.
From: “Non-Toxic” Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity
Toxin (Species) | Staining with NR | Staining with Lysotracker | Co-localisation | Effect of bafilomycin A1 | Ref. |
|---|---|---|---|---|---|
“Non-Toxic” complex (Clostridium botulinum) | Peripheral | Peripheral | Rab7, Rab9, Lamp1 | Inhibit | This article |
VacA (Hericobacter pylori) | Yes | Yes | Rab7, Lamp1 | Inhibit | |
Haemolysin (Vibrio cholerae) | Yes | NI | Rab7, TGN46, Lamp1 | Does not inhibit vacuole formation, but inhibits swelling of vacuoles | |
CARDS (Mycoplasma pneumoniae) | Yes | NI | Rab9, Lamp1, Lamp2 | Inhibit |
