Figure 7 | Scientific Reports

Figure 7

From: ZCF32, a fungus specific Zn(II)2 Cys6 transcription factor, is a repressor of the biofilm development in the human pathogen Candida albicans

Figure 7The alternative text for this image may have been generated using AI.

A proposed model for the regulation of biofilm development by ZCF32.

The transcription factor Zcf32 gets recruited more on the promoters of biofilm-induced genes in the planktonic mode of growth and represses their expression. Less expression of these genes results in less adhesion, yeast to hyphae transition and dispersion which in turn leads to reduced biofilm formation. However, in the biofilm mode of growth, there is decreased binding of Zcf32 on the promoters of biofilm-induced genes resulting in more expression of these genes. The increase in the expression level of biofilm-induced genes advances adhesion and following steps of biofilm development. Thus, we propose that the zinc cluster transcription factor, Zcf32, is a negative regulator of biofilm development in C. albicans.

Back to article page