Figure 4: Higher percentages of HHLA2 expressing tumor cells are associated with worse survival in osteosarcoma. | Scientific Reports

Figure 4: Higher percentages of HHLA2 expressing tumor cells are associated with worse survival in osteosarcoma.

From: HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival

Figure 4

Kaplan-Meyer curves were generated using multiple HHLA2 positive thresholds–specifically all HHLA2 positive, greater than 26% HHLA2 positive, and greater than 51% HHLA2 positive. (A) HHLA2 does not appear to be significantly associated with 5-year event free survival (5-yr EPS) when the positive threshold is set to ‘greater than zero’ (50% positive vs 61% negative, p = 0.45). (B,C) When the thresholds for positivity are set higher there are significantly worse 5-yr EPS for patients whose tumors are greater than 25% (64% vs 33%, p = 0.03) or 51% HHLA2 positive (59% vs 14%, p = 0.02) vs those that are not.

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