Table 2 HHLA2 and TIL/APC co-expression.

From: HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival

 

HHLA2

positive

HHLA2

negative

p-value

*PD-L1 positive

92%

8%

p = 0.006

*CD3 infiltration

70%

30%

p = 0.0004

CD8 infiltration

63%

37%

p = 0.24

CD4 infiltration

62%

38%

p = 0.38

*CD20 infiltration

78%

22%

p = 0.001

*CD1a infiltration

78%

22%

p = 0.001

CD56 infiltration

61%

39%

p = 0.22

*CD68 infiltration

67%

31%

p = 0.03

  1. HHLA2 expression is associated with specific immune infiltration. Tumors displaying infiltration by CD3+ T cells, CD20+ B cells, CD1a+ dendritic cells, and CD68+ macrophages were more likely to be HHLA2 positive.
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