Table 1 The pharmacokinetic parameters of CA, GA and PAE orally administrated 2 and 3 capsules.

From: Integrated identification, qualification and quantification strategy for pharmacokinetic profile study of Guizhi Fuling capsule in healthy volunteers

Parameters

2 capsules

3 capsules

CA

GA

PAE

CA

GA

PAE

Cmax (ng/ml)

107.24

4.36

3.00

148.15

6.14

3.46

Tmax (h)

1.0

2.2

3.0

0.9

2.1

2.7

t1/2 (h)

1.74

2.73

4.34

1.50

1.66

3.81

MRT (h)

2.55

4.88

7.40

2.25

3.29

6.63

AUC0-Ï„ (ng/ml*min)

144.13

8.62

10.66

210.66

13.44

14.81

AUC0-∞ (ng/ml*min)

164.66

12.60

16.94

227.25

15.44

20.70

F*

—

—

—

128.2%

229.8%

155.6%

AUC extrapolation ratio

12.0%

36.2%

33.0%

9.0%

24.0%

32.0%

  1. *compared with the parameters orally administrated 2 capsules.
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