Figure 2
From: Microbial Cryptotopes are Prominent Targets of B-cell Immunity
Evaluation of CI in healthy individuals.
(A) Whole CMV lysates were probed under native (ODTris) and denaturing (ODUrea) conditions with human immune sera from CMV-seropositive, healthy blood donors (n = 109) or from patients with primary CMV infection (n = 20). (B) Cryptotope index (CI) measured when testing human immune sera from CMV-seropositive, healthy blood donors (n = 109) at a standard serum dilution (1:500) in comparison to CI obtained when testing the same immune sera at higher dilutions (1:1500 and 1:4500, respectively). The dashed lines are references for similar signals obtained under native and denaturing conditions. Solid lines indicate linear regression plots for each group of patient samples.
