Table 5 Aqueous humor levels of 27 types of cytokines in subgroup A and subgroup B and changes after IVR.
|  | Subgroup A (n = 15) | Subgroup B (n = 24) | Preinjection (n = 11) | Postinjection (n = 11) | P Value | |
|---|---|---|---|---|---|---|
Subgroup A vs Subgroup B | Preinjection vs Postinjection | |||||
IL-2 | 1.3 (0–3.3) | 1.8 (0–11.2) | 2.0 (0–11.2) | 1.8 (0–2.8) | 0.187 | 0.028 |
IL-10 | 4.1 (2.8–6.1) | 5.0 (2.2–15.2) | 5.3 (2.2–15.2) | 2.4 (0–4.3) | 0.043 | 0.004 |
IL-15 | 6.6 (3.5–10.5) | 7.9 (0–27.8) | 8.1 (3.8–18.1) | 7.8 (3.1–10.3) | 0.112 | 0.175 |
IL-17 | 9.5 (0–15.1) | 9.8 (0–55.7) | 9.5 (0–55.7) | 9.2 (0–11.2) | 0.675 | 0.221 |
basic FGF | 13.4 (7.5–28.3) | 12.9 (5.0–88.4) | 12.5 (5.0–88.4) | 10. 0 (0–42.4) | 0.544 | 0.041 |
GM-CSF | 169.0 (114.2–291.8) | 171.8 (35.6–1450.1) | 207.6 (71.5–1450.1) | 165.4 (39.6–259.9) | 0.624 | 0.075 |
IL-1b | 0 (0–3.2) | 0 | 0 | 0 | 0.206 | — |
IL-1ra | 0 (0–12.0) | 5.0 (0–131.3) | 0 (0–131.3) | 0 (0–29.4) | 0.122 | 0.612 |
IL-4 | 0 | 0 | 0 | 0 (0–0.3) | — | 0.317 |
IL-5 | 0 | 0 | 0 | 0 | — | — |
IL-6 | 3.4 (0–7.5) | 3.0 (0–120.9) | 2.7 (0–120.9) | 4.5 (1.9–698.2) | 0.897 | 0.016 |
IL-7 | 1.6 (0–3.2) | 2.0 (0–3.6) | 2.1 (0–3.6) | 1.5 (0–3.4) | 0.056 | 0.663 |
IL-8 | 0 | 0 (0–4.5) | 0 (0–4.1) | 0 (0–16.5) | 0.100 | 0.317 |
IL-9 | 0 (0–2.0) | 0 (0–5.2) | 0 (0–1.4) | 0 (0–1.4) | 1.000 | 1.000 |
IL-12 | 10.0 (4.2–15.3) | 11.5 (0–25.0) | 10.3 (0–25.0) | 0 (0–9.1) | 0.238 | 0.008 |
IL-13 | 1.8 (0.6–6.5) | 2.0 (0–5.4) | 2.1 (0–5.4) | 1.7 (0.5–3.4) | 0.462 | 0.386 |
Eotaxin | 0 | 0 | 0 | 0 | — | — |
G-CSF | 0 | 0 | 0 | 0 (0–12.8) | — | 0.317 |
IFN-γ | 0 | 0 (0–9.6) | 0 | 0 (0–9.3) | 0.429 | 0.317 |
IP-10 | 59.4 (0–202.7) | 39.4 (0–407.4) | 32.2 (0–407.4) | 46.2 (1.6–1375.8) | 0.231 | 0.110 |
MCP-1 | 331.5 (180.7–443.7) | 346.4 (185.5–596.7) | 343.2 (206.1–476.8) | 311.2 (171.6–625.9) | 0.335 | 0.648 |
MIP-1a | 0.7 (0–1.1) | 0 (0.3–3.9) | 0 (0–3.9) | 0.7 (0–0.8) | 0.616 | 0.674 |
MIP-1b | 5.1 (1.9–13.3) | 7.9 (3.2–22.0) | 7.1 (3.2–13.5) | 7.0 (4.0–15.4) | 0.030 | 0.407 |
PDGF-bb | 0 | 0 | 0 | 0 | — | — |
RANTES | 0 | 0 | 0 | 0 | — | — |
TNF-α | 0 | 0 | 0 | 0 (0–5.4) | — | 0.317 |
VEGF | 37.5(18.5–69.1) | 44.8(17.6–108.8) | 40.3 (17.6–108.8) | 5.7 (0–59.9) | 0.097 | 0.003 |
