Figure 3: Mechanistic signaling model of HSPC in vitro culture. | Scientific Reports

Figure 3: Mechanistic signaling model of HSPC in vitro culture.

From: Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform

Figure 3

The linear model depicting the correlation between HSPC number, autocrine and paracrine signaling activity, cell-cell contacts, cell-ECM adhesion and heparin content of the microcavity arrays is illustrated. N: cell numbers; cx: concentrations of factor x; Ax: stimulative or inhibitory effect of factor x by autocrine signaling, n: cell-cell contacts (15 μm cavities: 1, 40 μm cavities: 3.6, planar: 6); Bx: stimulative or inhibitory influence of factor x by paracrine signaling, C: factor independent influence of cell - cell contacts; D: factor independent influence of adhesion to scaffold; a: material specific adhesion parameter (PDMS-FN: 1, TCP: 0.5, PEG-HEP&PEG-PEG: 0); E: stimulative or inhibitory effect of heparin; h: heparin content in the scaffold: (PEG-HEP: 1, PEG-PEG&PDMS-FN&TCP: 0).

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