Figure 5

Numbers of ectopic NADPH-positive cells in the SS and LM.

Each plot (boxes) indicates the number of NADPH+ cells in the subserosal (SS) and longitudinal muscle (LM) layers per damaged area, at each time point after BAC treatment (2 days–3 weeks). The means (bars) are also plotted at each time point for both wildtype (W) and W/W^v mice. No NADPH+ cells were observed in either wildtype or W/W^v derived samples during the first week of BAC treatment (wildtype 2 days, n = 3, W/W^v 2 days, n = 3, wildtype 1 week, n = 3, W/W^v 1 week, n = 3). On weeks 2 and 3 after BAC treatment, the average number of cells was 3.9 ± 2.4 (mean ± SEM, n = 7) and 10.6 ± 3.9 (n = 7), respectively, per damaged area for wildtype mice. On weeks 2 and 3 after BAC treatment, the average number of cells was 15.1 ± 6.0 (n = 8) and 59.2 ± 17.6 (n = 6), respectively, for W/W^v mice. The increase in NADPH-positive cells in W/W^v mice compared with that in wildtype mice was statistically significant at 3 weeks after treatment (*P < 0.05).