Figure 6 | Scientific Reports

Figure 6

From: Suppression of c-Kit signaling induces adult neurogenesis in the mouse intestine after myenteric plexus ablation with benzalkonium chloride

Figure 6

Imatinib induced appearance of NADPH-positive cells in the SS and LM of wildtype mice.

(a) The normal ileum without BAC ablation showed networks of myenteric plexus. There were no neurons beyond the myenteric plexus layer. Ectopic NADPH-positive cells appeared in wildtype mice after BAC treatment in the presence of vehicle (b) or imatinib (c). Scale bar, 200 μm. (d) The number of NADPH-positive cells following treatment with vehicle or imatinib in wildtype mice (boxes) 3 weeks after BAC treatment. The average number of ectopic NADPH-positive cells in wildtype mice treated with vehicle and imatinib were 10.6 ± 3.9 (n = 7) and 103.4 ± 36.1 (n = 8), respectively (*P < 0.01).

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