Figure 5
Anti-Trichuris effects of compounds (1–6) against T. muris determined using the xWORM technique.
(A) Effects of different concentrations of compounds 1–6 were assessed on adult worm motility. 50% inhibitory concentration (IC50) values were determined at the 12 h time point. (B) Combined IC50 values of these six compounds calculated for three different doses at 1, 6 and 12 h time points. Error bars represent 95% confidence intervals of the nonlinear curve fit. The curves were marginally shifted on the x-axis to aid viewing. These figures represent the data from three independent experiments.
