Figure 2

The correlations of effect size and study quality or clinical variables across studies.

Bivariate analyses confirmed that study quality was little related to NSCs interventions in infarct volume (a) and the effect size of mNSS and Rotarod test were significant positive correlation with study quality (b,c). Furthermore, the effect size of infarct volume or mNSS across studies has a certain correlation to clinical variables type of NSCs source (e) and time of NSCs administration relates to stroke onset (d,f). (g,h) The correlations of the effect size (mNSS and infarct volume) and the use of immunosuppression in 9 reported studies (14 interventions), respectively (mNSS: p = 0.038, Infarct Volume: p = 0.048). hNSC (rNSC or mNSC) = human NSC (rat or mouse NSC); hNSC + χ = human NSC + cytokines (e.g. VEGF).