Figure 7
A diagram showing metabolism in the ischemic, penumbra and distant normoxic regions.
Heterogeneity in carbohydrate metabolism in and around ischemic myocardium in the early phase of left anterior descending coronary artery (LAD) ligation. Ischemic region: • A marked reduction in energy charge due to impaired energy production in mitochondria due to lack of oxygen (NADH, succinate accumulation). • A large increase in glucose uptake, an accelerated rate of glycolysis and lactate production. • Lactate uptake is maintained and its catabolism using the Krebs cycle increases. Non-ischemic region (including penumbra and normoxic region): • A lower energy charge than a normal myocardium from a sham-operated mouse due to high energy expenditure to compensate functionally for the loss of working myocardium. • An increase in the uptake of glucose and lactate. • Activation of glycolysis and entry of glycolytically derived pyruvate into the Krebs cycle. Penumbra region: • Higher energy charge and a lower lactate/pyruvate ratio than regions more distant. • The preferential entry of glycolytically derived pyruvate into the Krebs cycle.
