Figure 8

Model of a mechanism by which physapubescin down-regulates the expression of HIF 1/2α and selectively up-regulates the expression of CHOP and DR5 leading to apoptosis in VHL-null RCC cells but not in VHL wild-type RCC cells.

Model of a mechanism by which physapubescin down-regulates the expression of HIF 1/2α and selectively up-regulates the expression of CHOP and DR5 leading to apoptosis in VHL-null RCC cells but not in VHL wild-type RCC cells.