Figure 2 | Scientific Reports

Figure 2

From: Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expression

Figure 2

MiR-370-3p sensitized the response of glioma cells to temozolomide.

(A) Innate sensitivity to TMZ in two lowest (LN18, T98G) and one highest miR-370-3p expressed cell line (U87). (B) LN18 was transfected with miR-370-3p mimics and scrambled control miRNA. (C) Cell proliferation confirmed that miR-370-3p mimic cells were more sensitive to TMZ than controls (*P < 0.05). (D) Cell colony formation miR-370-3p mimic cells were more sensitive to TMZ than controls (*P < 0.05). The colony forming ability of miR-370-3p mimics cells were significantly decreased following 24 hours of the TMZ treatment.

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