Figure 7
The effect of miRNA 3180-5p on the cell cycle.
The expression of miRNA 3180-5p and PODN in patient samples. (a,b) The proliferation index, which is the percent of (S + G2/M), increased from 29.32 ± 6.25 in the NC group (non-targeting control sequence-treated cells) to 50.50 ± 3.41 in the miR 3180-5p mimics group (p = 0.002). The miR 3180-5p promoted cell transformation from the G1 to S phase. After induction of hydrostatic pressure, the expression of miRNA 3180-5p was up-regulated ((c,d) p < 0.00001), while the expression of PODN was down-regulated ((e,f) p < 0.00001).
