Figure 1 | Scientific Reports

Figure 1

From: Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Figure 1

Bexarotene treatment reduces lesion size in P301L-Tau TG mice but not in WT animals.

(A) Representative MRI images taken 72 h post ischemia. Bexarotene was administered orally at a dose of 100 mg/kg/day immediately after surgery and subsequently on days 1 and 2 after ischemia. (B) Lesion volumes were calculated from MRI images at 3 days post ischemia with Shuaib’s indirect method (infarct volume = [volume of left hemisphere − (volume of right hemisphere − measured infarct volume)]/volume of left hemisphere). Unpaired t-tests within genotypes, TG p = 0.048 N = 12–17/group. *p < 0.05. Veh = vehicle treated animals, Bex = bexarotene treated animals.

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