Figure 8 | Scientific Reports

Figure 8

From: Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Figure 8

Bexarotene treatment restores mitochondrial function of P301L-Tau neurons in vitro.

(A) Left panel: Traces of oxygen consumption rates (OCR) of WT and P301L-tau cortical neurons as measured with Seahorse XF analyzer by sequential additions of mitochondrial effectors at time points indicated by arrows. Right panel: OCR traces of WT and P301L-tau cortical neurons treated for 24 h with 0.5 μM bexarotene prior to analysis. (B) Percentages of Oxphos-coupled OCR and mitochondrial maximal respiration OCR normalized to baseline at time zero. Unpaired t-test between genotypes, oxphos-coupled OCR p = 0.019, mitochondrial maximal respiration p < 0.001 N = 4/group. Data are shown as means ± SEM. *p < 0.05, ***p < 0.001.

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