Figure 2 | Scientific Reports

Figure 2

From: Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways

Figure 2

Identification of metabolic subpathways associated with prostate cancer.

(A) Plots of pathway significance (–log10 P-value) in Subpathway-CorSP, Pathway-G, Pathway-M, IMPaLA and Subpathway-GM. Subpathway-CorSP identified 20 significant metabolic subpathways, corresponding to 20 entire pathways. Plus sign, pathway was identified by the corresponding method at the 5% significance level. Bold labels, additional pathways identified only by Subpathway-CorSP. (B) Boxplot of average Pcc value for the 20 significant subpathways, the corresponding 20 entire pathways and all metabolic pathways. Average Pcc value for the 20 significant subpathways was significantly higher than for the corresponding 20 entire pathways (P = 2.861e-06) and significantly higher than for all metabolic pathways (P = 1.271e-05).

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