Table 2 The significant subpathways identified by Subpathway-CorSP using prostate cancer data set (P < 0.05).

From: Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways

Subpathway ID

PathwayName

Subpathway-CorSP

Pathway-G

Pathway-M

IMPaLA

Subpathway-GM

Possible relation to the cancer

Reference (PMID)

path:00260_1

Glycine, serine and threonine metabolism

0.00024269

0.52409080

0.16216414

0.08498874

0.00017964

De novo Purine synthesis

19063642; 15229480

path:00563_1#

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

0.00096023

0.39629916

1

1

1

Suppress invasion of prostate and breast cancer cells

16822939

path:00510_4#

N-Glycan biosynthesis

0.00137850

0.11717815

1

1

1

Efficient detection of prostate cancer

18701493; 25154914

path:00562_1

Inositol phosphate metabolism

0.00339828

0.19556203

0.44168527

0.08637687

0.00760810

Membrane receptor signaling cascades and anti-cancer activity

14608114; 20414202

path:00340_1

Histidine metabolism

0.00396946

0.47151833

0.13647964

0.06435265

0.00289440

Cell proliferation

16203768; 18347416

path:00910_1

Nitrogen metabolism

0.00434048

0.72281060

0.0552906

0.03996463

0.01352617

Enhance anti-cancer activity

23746196; 26174441

path:00561_1#

Glycerolipid metabolism

0.00464301

0.93511527

0.38902790

0.36378593

0.29439641

High energy demand and cell propagation

18757836; 21802006

path:00601_1

Glycosphingolipid biosynthesis - lacto and neolacto series

0.00573235

0.16469429

1

1

0.02863259

Cell adhesion and the growth of tumor cells

20428086; 19658179

path:00052_1

Galactose metabolism

0.00657521

0.16469429

0.02167594

0.00356990

1

Toxic to ovarian cells

25586565; 21335998

path:00010_1

Glycolysis/Gluconeogenesis

0.00947690

0.46000521

0.37041772

0.17039408

0.00059735

Energy demand of colorectal cancer tissues

19678709; 19063642

path:00030_1

Pentose phosphate pathway

0.00962547

0.05589567

0.01106147

0.00061828

0.00040717

Increase cytotoxicity and oxidative stress

25560241; 24861463

path:00270_2#

Cysteine and methionine metabolism

0.01530709

0.12895515

1

1

1

Prostate cancer cell invasion and aggressivity

20718469; 21853037

path:00620_1

Pyruvate metabolism

0.01530709

0.64619119

1

1

0.04290499

Maintain of colon cancer cells

20919825; 18789002

path:00360_1#

Phenylalanine metabolism

0.02129967

1

0.23763160

1

1

High metabolic rate in cancer

20919825; 18789002

path:00330_1

Arginine and proline metabolism

0.02749154

0.95093432

0.00182141

0.00173204

2.96E-05

Colon cancer inhibition and tumoral energy production

20919825; 19678709

path:00983_4#

Drug metabolism-other enzymes

0.02828285

0.78112433

1

1

1

Metabolism of anti-cancer drug

21215737; 21533940

path:00450_1#

Selenoamino acid metabolism

0.02872727

0.16469429

1

1

0.07222314

As inhibitors of histonedeacetylase in human prostate cancer cells

19584079; 15041072

path:00670_1#

One carbon pool by folate

0.02897254

0.25510731

1

1

1

 

—

path:00770_1

Pantothenate and CoA biosynthesis

0.03578242

0.21421764

0.00686790

0.00147122

1

 

—

path:00480_1

Glutathione metabolism

0.04742966

0.93864190

0.01768909

0.01660372

0.00389595

Impact resistance of cancer cells

26056813; 25144624

  1. Subpathways with # symbol are uniquely identified by Subpathway-CorSP.
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